
4,5-Dicaffeoylquinic acid
CAS No. 57378-72-0
4,5-Dicaffeoylquinic acid ( Isochlorogenic acid C )
产品货号. M18835 CAS No. 57378-72-0
Isochogenic Acid C(4, 5) 具有抗病毒活性,包括抗 HIV-1 整合酶活性。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥656 | 有现货 |
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10MG | ¥948 | 有现货 |
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25MG | ¥1555 | 有现货 |
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50MG | ¥2292 | 有现货 |
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100MG | ¥3386 | 有现货 |
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500MG | ¥8043 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称4,5-Dicaffeoylquinic acid
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Isochogenic Acid C(4, 5) 具有抗病毒活性,包括抗 HIV-1 整合酶活性。
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产品描述Isochlorogenic acid C(4, 5) has antiviral activity, including anti-HIV-1 integrase activity. Isochlorogenic acid C(4, 5) shows anti-hepatotoxic activity.
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体外实验4,5-Dicaffeoylquinic acid (0.1~100 μM; 72 h) has dose-dependent inhibitory activity against DU-145 prostate cancer cells, and induces cell cycle arrest, also induces inactivation of Bcl-2.4,5-Dicaffeoylquinic acid (1~100 μg/mL; 48 h) has anti-apoptotic effect in D-GalN-challenged HL-7702 hepatocytes, and improves significantly cell viability at concentrations of 10 to 100 μg/mL.4,5-Dicaffeoylquinic acid (1~100 μg/mL; 4 days) inhibits significantly expressions of HBsAg and HBeAg, and produces the maximum inhibition rates of 86.93 and 59.79% at 100 μg/mL on expressions of HBsAg and HBeAg, respectively. Cell Proliferation Assay Cell Line:DU-145 cells Concentration:0.1~100 μM Incubation Time:72 h Result:Exhibits dose-dependent inhibitory activity against DU-145 prostate cancer cells with an IC50 of 5 μM.Cell Cycle Analysis Cell Line:DU-145 cells Concentration:5 μMIncubation Time:72 h Result:Decreased in numbers in G0/G1 phase and increased in S phase.Apoptosis Analysis Cell Line:HL-7702 hepatocytes (exposure to 60 mM D-GalN for 6h) Concentration:1~100 μg/m L Incubation Time:48 h Result:Significantly reduced the caspase-3 and transforming growth factor β1 (TGFβ1) levels of the D-GalN-challenged hepatocytes at 10~100 μg/mL.Cell Viability Assay Cell Line:HL-7702 hepatocytes (exposure to 80 mM D-GalN for 6h) Concentration:1~100 μg/mL Incubation Time:48 h Result:Improved significantly cell viability at concentrations of 10 to 100 μg/mL, and produced a maximum protection rate of 47.28% at 100 μg/mL.
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体内实验4,5-Dicaffeoylquinic acid enhances the expression of GLUT2, GK, and PDX-1 protein, and effectively alleviate glycaemia and insulin resistance and enhance insulin sensitivity in type 2 diabetic mice.
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同义词Isochlorogenic acid C
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通路Others
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靶点Other Targets
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受体Others
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研究领域Infection
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适应症——
化学信息
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CAS Number57378-72-0
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分子量516.45
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分子式C25H24O12
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纯度>98% (HPLC)
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溶解度DMSO : 50 mg/mL 96.81 mM
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SMILESC1C(C(C(CC1(C(=O)O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)OC(=O)C=CC3=CC(=C(C=C3)O)O)O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册




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